The last day of third grade is approaching fast, but a farewell to Room 3B isn't the only goodbye Doug has to say this year. Song Lee and Mary are busy preparing an end-of-year present for their favorite teacher, Mrs. Flaubert, but their excitement can't distract Doug from Harry's suspicious silence.

When Harry finally admits that his family is moving to a whole other town, Doug can't believe his ears. How will he survive fourth grade without his best friend?! But Harry has a more pressing question: who's that moving in to the empty house across the street from him? And what could these new neighbors mean for their friendship?