Rajiv J. Shah is no stranger to pulling off the impossible, from helping vaccinate 900 million children at the Bill & Melinda Gates Foundation to a high-pressure race against the clock to stop the spread of Ebola. His secret? A big bets philosophy—the idea that seeking to solve problems rather than make incremental improvements can attract the unlikely partners with the power and know-how to achieve transformational change. Part career sweeping memoir, part inspirational playbook, Big Bets offers a master class in decision-making, leadership, and changing the world one bet at a time.

Shah animates his strategic insights with vivid behind-the-scenes stories, memorable conversations with household names that helped shape his approach to creating change, and his own personal growth as an Indian-American from an immigrant family looking for a way to belong. He distills his battle-tested strategies for creating change, arguing that big bets have a surprising advantage over cautious ones: a bold vision can attract support, collaborations, and fresh ideas from key players who might otherwise be resistant. Throughout the book, Shah traces his unlikely path to the Rockefeller Foundation across a changing world and through some of the most ambitious, dramatic global efforts to create a better world.